Keto Versus Mediterranean Weight-reduction plan: Which Is Greatest for T2 Diabetics and Prediabetics?

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Impact of a Ketogenic Weight-reduction plan versus a Mediterranean Weight-reduction plan on HbA1c in People with Prediabetes and Sort 2 Diabetes Mellitus: the Interventional Keto-Med Randomized Crossover Trial

Proper off the bat, I do not like that they studied each diabetes and prediabetics. There have been solely 40 unique research members, with full knowledge on solely 33. Why lump the 2 collectively?

Members adopted every food regimen for 12 weeks then lab knowledge and physique weight have been assessed.

The researchers conclusions:

HbA1c [a measure of blood sugar control] was not totally different between food regimen phases after 12-weeks, however improved from baseline on each diets, seemingly as a result of a number of shared dietary elements. WFKD [ketogenic diet] was useful for better lower in triglycerides, but in addition had potential untoward dangers from elevated LDL-C, and decrease nutrient intakes from avoiding legumes, fruits, and complete intact grains, in addition to being much less sustainable.

Triglycerides dropped extra on the keto food regimen, no shock. Physique weight dropped the identical for each diets, 7-8%. HDL-cholesterol (the “good ldl cholesterol”) rose 11% on keto and seven% on the Mediterranean food regimen. HgbA1c dropped the identical on each diets, about 8% from baseline. Each diets result in consuming ~300 energy much less per day than baseline consumption.

Dr Bret Scher addressed the elevated LDL-cholesterol (aka “unhealthy ldl cholesterol”) over at

The authors reported that LDL “dangerously” rose 10% on the keto food regimen. However was it actually a harmful change? Triglycerides went down on the keto food regimen, as we might count on. And as we noticed in 2018 with the Virta Well being trial, on common, LDL went up 10%. Nevertheless, the calculated cardiac danger rating went down 12%.

When it comes to answering the headline query, Keto Versus Mediterranean Weight-reduction plan: Which Is Greatest for T2 Diabetics and Prediabetics?, the reply actually relies on long-term knowledge regarding longevity and varied ailments. This research would not reply the query.

What say you?

Steve Parker, MD

front cover of Conquer Diabetes and Prediabetes